2nd International Conference on
and  Health
October 4-7, 2005,  Davis, California

Final Schedule

Opening Keynote Addresses,  Tuesday October 4, 4:00 pm, ARC Ballroom
Chairs, A. Waterhouse, C. Fraga

Neal Van Alfen, Dean, College of Agricultural and Environmental Sciences
Welcome to University of California, Davis

Carlo La Vecchia, Mario Negri Pharmacology Research Institute, Milan, Italy
Diet and cancer risk in Mediterranean countries

Carl L. Keen, University of California, Davis, USA
Polyphenols, epicatechin and vascular function: an insight into the health benefits of diets rich in fruits and vegetables

Basic aspects of polyphenol action in biological systems
Wednesday October 5, 8:30 am, ARC Ballroom
Chairs: L. Packer, B. Halliwell

Barry Halliwell, National University of Singapore, Singapore
Are flavonoids really antioxidants in vivo?

Agapios Sachinidis,
University of Köln, Germany
Mechanisms of the inhibitory effects of the polyphenols catechins on the platelet-derived growth factor-induced cell signaling and mitogenesis

Balz Frei, Linus Pauling Institute, Oregon State University, Corvallis, USA
Differential antioxidant and biological effects of flavonoids or flavonoid-rich foods in vitro and in vivo

Sam Possemiers, University of Ghent, Belgium
Activation of pro-estrogens from hops (humulus lupulus l.) by intestinal bacteria

Richard A. Anderson, Human Nutrition Research Center, Beltsville, USA
PCR analyses demonstrate that tea increases insulin sensitivity and insulin signaling in rats with metabolic syndrome

10:15 Break

Chairs: L. Packer, H. Sies

Helmut Sies,
Heinrich-Heine University Duesseldorf, Germany
Flavonoids from cocoa and vascular responses

Valerie B. Schini-Kerth,
University of Louis Pasteur, Strasbourg, France
Vascular protection by polyphenols

Jeffrey Blumberg, Tufts University, Boston, USA
Bioavailability and antioxidant activity of almond skin polyphenols

Kayoko Shimoi, University of Shizuoka, Japan
Inhibitory effects of  quercetin metabolites on peroxynitrite-induced oxidation and tyrosine nitration of human serum albumin and cellular proteins

Consuelo Borras, University of València, Spain
Dietary soy isoflavones enhance antioxidant gene expression mediated by MAPK/NFkB signalling pathways

12:30 Lunch, Pavillion

Polyphenols in cardiovascular disease
Chairs: F. Booyse, I. Jialal

Francoise Booyse, University of Alabama, Birmingham, USA
Molecular mechanisms underlying polyphenol-induced cardioprotection

Ramaroson Andriantsitohaina, University of Louis Pasteur, Strasbourg, France
Protective effect of polyphenols on vascular diseases linked to oxidative stress

Francisco Perez Vizcaino, University of Complutense, Madrid, Spain
Flavonoids: hypertension and endothelial dysfunction

Tankred Schewe, Heinrich-Heine
University Duesseldorf, Germany
Protective actions of (–)-epicatechin on endothelial cells.  Comparison with antioxidant vitamins and aspirin

Myron Gross, University of Minnesota, Minneapolis, USA
The effect of black tea intake on several cardiovascular disease-related activities in individuals with mild hypercholesterolemia

3:15 Break

Chairs: D. Das, I. Jialal

Kevin Croft, Royal Perth Hospital, Australia

Antiatherogenic polyphenols: effects are independent of antioxidant actions

Dipak Das, University of Connecticut Health Center, Farmington, USA
Red wine and heart: a journey from grape to resveratrol

Giovanni Mann, King’s College, London, UK
Regulation of antioxidant gene expression vascular cells by dietary isoflavones

Wilhelmina Kalt, Agriculture and Agri-Food Canada, Kentville, Nova Scotia, Canada
Effects of blueberry supplementation on cvardiovascular parameters in relation to food matrices

Jennifer Donovan, Medical University of South Carolina, Charleston, USA
Short -term administration of (-)-epigallocatechin gallate reduces hepatic fat content and protects against hepatic ischemia/reperfusion Injury in steatotic mice

Split Session, Part A
Polyphenol metabolism
Thursday October 6, 8:30 am, ARC Ballroom A
Chairs: J. Terao, A. Scalbert

Junji Terao, The University of Tokushima, Japan
Metabolic conversion of polyphenols and regulation of their biological effect

Michael Blaut, German Institute for Nutritional Research,  Potsdam-Rehbrücke, Germany

Influence of intestinal bacteria on bioavailability of polyphenols

Johanna W. Lampe, Fred Hutchison Cancer Research Center, Seattle, USA
Characterizing daidzein-metabolizing phenotypes in population-based studies

Rosa M. Lamuela-Raventos, University of Barcelona, Spain

Milk does not impair the bioavailability of flavonoids from cocoa powder

Alyson E. Mitchell, University of California, Davis, USA
Identification of glutathione conjugates of quercetin in human urine and murine heptocyte suspensions

10:15 Break

Chairs: A. Crozier, G. Williamson

Alan Crozier, University of Glasgow, UK
Bioavailability and metabolism of dietary phenolics

Gary Williamson, Nestlé, Lausanne, Switzerland
The complex relationship between polyphenol metabolism and biological activity

Ron Prior, Arkansas Children's Nutrition Center, Little Rock, USA
Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities

Marie-Noëlle Horcajada, INRA at Clermont Theix, St. Genes Champanelle, France
Hesperetin-7-glucoside is more efficient than hesperidin in improving bone metabolism in adult rats

Heidrun Gross, University of California, Davis, USA
Improved method for simultaneous determination of flavanols and their Metabolites in human plasma and its application in clinical trials

12:30 Lunch

Food composition and polyphenol effects on health
Chairs: F. Tomas-Barberan, A. Mitchell

Francisco Tomas-Barberan, CEBAS-CSIC, Murcia, Spain

How relevant is in vitro antioxidant activity? The case of ellagic acid and related phenolics

Federico Leighton, Catholic University of Chile, Santiago, Chile

Wine and Mediterranean diets, high in polyphenols, protect against the metabolic syndrome through enhancement of eNOS

Mauro Serafini, INRAN, Rome, Italy
Total antioxidant capacity of plant foods and disease prevention: results from in-vivo and epidemiological studies

Valeria Acquarone, Masterfoods, Hackettstown, USA

Isomerization of (-)-epicatechin under typical food processing conditions: influence of pH and temperature on the transformation kinetics

Salka Elboel Rasmussen, Danish Institute for Food and Veterinary Research, Soeborg, Denmark

Health protective effects of fruits, vegetables and other polyphenol rich diets. Use and validation of new biomarkers for intake of dietary polyphenols

3: 15 Posters

Split Session, Part B

Polyphenols in cancer
Thursday October 6, 8:30 am, ARC Ballroom B
Chairs: B. Aggarwal, P. Oteiza

Bharat B. Aggarwal, University of Texas, Houston, USA
Targeting transcription factor NF-k
B by dietary agents for cancer and other inflammatory diseases

Hasan Mukhtar, University of Wisconsin, Madison, USA
Polyphehols from green tea for prevention of prostate cancer

Patricia Oteiza, University of California, Davis, USA
Dimeric flavanols in the modulation of NF-kB as an anticancer strategy

Claudine Manach, INRA at Clermont Theix, St. Genes Champanelle, France
Bioavailability of isoflavones in human prostate

Susanne Henning, University of California, Los Angeles, USA
Colonic metabolites of flavonoids from tea, citrus and soy and their antiproliferative activity

10:15 Break

Chairs: H. Mukhtar,  N. Latruffe

Norbert Latruffe, University of Burgundy, Dijon, France
Resveratrol as cancer chemopreventive agent; new concepts to improve efficacy

Spiridione Garbisa, University of  Padova, Italy
The twin faces of hyperforin, a cancer fighting-antidepressant

Francis Raul, University of Louis Pasteur, Strasbourg, France
Metabolic and signal transduction perturbations asociated with cancer cell death triggered by apple polyphenols

Sandra Ulrich, J.W. Goethe University, Frankfurt, Germany
Resveratrol modulates polyamine metabolism of colorectal cancer cells via two different signal transduction pathways

Susan Zunino, Western Human Nutrition Research Center, USDA, Davis, USA
Disruption of mitochondrial homeostasis and induction of apoptosis in acute leukemia cells by polyphenols

12:35 Lunch

Polyphenols in neurodegeneration
Chairs: S. Mandel, P. Maher

Silvia Mandel, Technion-Faculty of Medicine, Haifa, Israel
Multifunctional activities of green tea catechins in neuroprotection: modulation of cell survival genes, irondependent oxidative stress and PKC-signaling pathway

Pamela Maher, Salk Institute, San Diego, USA
The neurotrophic activities of flavonoids

Orly Weinreb, The Eve Topf and USA National Parkinson Foundation Center, Haifa, Israel

Neurorescue/Neuroprotective activity of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, compared with the anti-parkinson drug, rasagiline

Severine Talavera, University of Auvergne, Clermont-Ferrand, France
Anthocyanin metabolism in rats and their distribution to digestive area, kidney and brain

Dilip Ghosh, Horticulture & Food Research Institute, Auckland, New Zealand

Cytoprotective effects of anthocyanins and other phenolics of boysenberry and blackcurrant on dopamine and amyloid beta-induced oxidative stress in transfected COS-7 cells

3:15 Posters

New aspects of polyphenol physiology: nutragenomics and metabolomics
Friday October 7, 9:00 am, ARC Ballroom
Chairs: S. Barnes, J. Vina

Elaine Holmes
, Imperial College, London, UK
The role of metabolomics in exploring the metabolic consequences of polyphenols

Jose Vina, University of Valencia, Spain
Modulation of gene expression by estrogenic compounds. Importance for determining the different longevity between genders

Vincent de Boer, RIKILT-Institute of Food Safety, Wageningen, The Netherlands
Large scale gene expression study of quercetin exposed rats with lungs as selected target organ

Roger Corder, Queen Mary's School of Medicine and Dentistry, London, UK
Microarray analysis of endothelial responses to cranberry and red wine procyanidins identifies a wide range of vascular actions

Theo Mulder, Unilever, The Netherlands
Are green and black tea metabolically equal? A 1H-NMR spectroscopy-based metabolomic study

Yoshino Kiso, Suntory, Osaka, Japan
Modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver

10:50 Break

Stephen Barnes, University of Alabama, Birmingham, USA
Thinking outside of the box - discovering new (real) targets of polyphenols

Round-Table Discussion

Closing Remarks

putah creek

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